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Toothbrushes are the most important instrument in maintaining of oral hygiene. At first they were made from primitive materials that grew their own bacteria but today we have toothbrushes that do their job much better.
Except with dentures, missing teeth can be replaced with dental implants. People made and used dental implants since some 4000 years ago, using bamboo pegs and seashells instead of missing teeth.
Dental floss has a history that his maybe longer than of the toothbrush but we know for sure that it is in use since the 19th century. It is in the wider use since the invention of synthetic materials like nylon.
Tooth decay is one of the oldest diseases of the human race. People had caries for millions of years and still have it today. With the appearance of sugar cane and other types of sugar prevalence of caries increased and until the modern treatments of caries, both preventive and remedial, lessen the number and seriousness of caries cases.