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Toothpaste is one of the main ingredients in the process of keeping the teeth healthy. In combination with toothbrush it removes dental plaque and food that remains on the teeth after eating. Read more about history of toothpaste.
Toothbrushes are the most important instrument in maintaining of oral hygiene. At first they were made from primitive materials that grew their own bacteria but today we have toothbrushes that do their job much better.
Since the ancient times, we try to keep our mouth and teeth clean. Until we found out how bacteria work, we used some pretty unsanitary methods for that but in time we learned and today our hygiene standards are pretty high. Read more about history of oral hygiene.
Except with dentures, missing teeth can be replaced with dental implants. People made and used dental implants since some 4000 years ago, using bamboo pegs and seashells instead of missing teeth.