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Except with dentures, missing teeth can be replaced with dental implants. People made and used dental implants since some 4000 years ago, using bamboo pegs and seashells instead of missing teeth.
History of dentistry is long and ... well - painful. But since the people began using natural ingredients to treat illnesses, they used it for teeth problems also. And slowly but surely, we became more adept in treating tooth decay and other oral problems.
Since ancient times we had problems with crooked teeth. They interfered with proper eating and were not too aesthetically pleasing. Because of that, we tried to invent mechanical aids that helped us to fix them. Read about history of orthodontics.
Toothpaste is one of the main ingredients in the process of keeping the teeth healthy. In combination with toothbrush it removes dental plaque and food that remains on the teeth after eating. Read more about history of toothpaste.